Ongoing Clinical Projects 2017-2018

Aravind Eye Hospitals & Postgraduate Institute of Ophthalmology


Glaucoma
  • A Clinical Validation Study for evaluating the performance of RIA-G software for automated detection of optic nerve head changes on fundus photographs/images
  • Validation of the Compressed Assessment of Ability Related to Vision (CAARV), a Performance Based Measure, in a South Indian Population with Glaucoma
  • A correlative study of pupillary response as measured by automated monocular pupillometer (Neuroptics plr™-3000) with Retinal Nerve Fiber layer thickness and visual field in varying severities of glaucoma
  • Surgical outcome of piggyback intraocular lens implantation after phacoemulsification in nanophthalmic eyes
  • Endothelial cell loss after Phacoemulsification in nanophthalmic eyes undergoing cataract surgery
  • Clinical and histopathological correlation of the sclera in nanophthalmic eyes undergoing cataract surgery
  • Robison D. Harley, MD CGRN International Pediatric Glaucoma Registry
Cataract
  • The Natural History of Artificial Intraocular Lenses in Eyes with Exfoliation Syndrome (APEX IOL Study)
  • Prostaglandin level estimation in phacoemulsification and Femtosecond laser assisted cataract surgery with and without NSAID and correlation with postoperative inflammation and cystoid macular edema
  • Prospective intracameral moxifloxacin endothelial safety study in patients having cataract surgery comparing 500 mcg/0.1 ml in one eye and 250 mcg/0.1ml in the opposite eye.
  • Evaluation of posterior capsular changes, IOL glistening and visual outcome after implantation of VivinexTM intraocular lens (IOL) in routine clinical practice
  • Visual Outcomes of SMART SICS
  • A retrospective study of causes of poor visual outcome in cataract surgery patients (phacoemulsification)
  • Comparative study of pre-operative reference marking for Toric Intraocular lens by manual toric marker over slit-lamp and by electronic device (ASICO TORIC MARKER)
  • Comparison of Intraoperative Posterior Capsular Rent (PCR) and Zonular dialysis (ZD) in Mature cataracts in SICS and Phacoemulsification at Aravind Eye Hospital Madurai
Retina
  • Microperimetry biofeedback training in patients with irreversible bilateral vision deterioration
  • CLS1003-301, SAPPHIRE: A randomized, masked, controlled trial to study the safety and efficacy of suprachoroidal CLS-TA in conjunction with IntravitrealAflibercept in subjects with Retinal Vein Occlusion
  • ARDA (Automated Detection Algorithm) Assisted Read Study Protocol - ADRES related Study
Uvea
  • Efficacy and safety of posterior subtenon's triamcinolone acetonide,intravitreal triamcinolone acetonide,intravitreal bevacizumab,intravitreal ozurdex for treatment of uveitic cystoid macula edema
  • First-Line Antimetabolites as Steroid-sparing Treatment (FAST)Uveitis Trial
Pediatric
  • Visual functions as determinants and VEP as predictor of response to the treatment in Amblyopia
  • Visual dysfunction in Autism Spectrum Disorders
  • Safety and efficacy of E/d Atropine 0.01% for control of progression of myopia
  • Study of accommodation in patients with Idiopathic Infantile Nystagmus (IIN)
  • AEH – Orbis Refractive Error among Children (REACH) Project
  • Assessment of distance and near stereoacuity, fusional amplitudes in patients with IXT and their change after surgery
  • Assessment of reading visual acuity in patients with nystagmus
  • Translational genomics of paediatric eye diseases
Low vision
  • Hospital anxiety and depression scale assessment of patients with low vision before and after using low vision care: A prospective study in a tertiary eye-care setting
Neuro-ophthalmology
  • Quantification of Relative Afferent Pupillary Defect (RAPD) by an automated pupillometer (RAPID) and its relationship to visual acuity, color vision, visual fields before and after treatment of patients with optic neuritis and Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
Cornea
  • To compare Spectral Domain Optical Coherence Tomography (SDOCT) and Pentacam to assess corneal scars
  • Impact of aberrations post Descemet?s stripping endothelial keratoplasty on visual outcome comparing methods of specimen collection in deep keratitis cases
  • Parasitic ulcer treatment trial
  • Mycotic ulcer treatment trial
  • Acanthamoeba Keratitis longitudinal study
Orbit
  • National retinoblastoma registry - ICMR
  • Translational Research to Generate Corneal/Buccal Epithelial Stem Cells with GMP Compliance for Corneal Surface and Socket Reconstruction
  • Identification of mitochondrial biomarkers in retinoblastoma
  • Clinical evaluation of silicone implant for primary or secondary volume rehabilitation of anophthalmic sockets
  • An open label, prospective clinical evaluation of safety and efficacy study of Aurostent (Silicone mono canalicular lacrimal stent manufactured by Aurolab, Madurai, India) in the treatment of canalicular injuries and anomalies
  • Establishing the genetic testing centre for childhood ocular cancer (retinoblastoma) in Aravind Medical Research Foundation

Ongoing Clinical Projects 2012-2013

Aravind Eye Hospitals & Postgraduate Institute of Ophthalmology


Cornea
  • To compare Spectral Domain Optical Coherence Tomography (SDOCT) and Pentacam to assess corneal scars
  • Impact of aberrations post Descemet?s stripping endothelial keratoplasty on visual outcome comparing methods of specimen collection in deep keratitis cases
  • Parasitic ulcer treatment trial
  • Mycotic ulcer treatment trial
  • Acanthamoeba Keratitis longitudinal study
Glaucoma
  • Study of factors affecting adherence to glaucoma treatment protocol
  • Effect of VEGF levels in Tenon tissue on the outcome of glaucoma surgery
  • Evaluation of cell adhesion properties of Aurolab Artificial Drainage Implant in comparison with Baerveldt Implant.
  • A 3-month, open-label, non-comparative, observational study of Bimatoprost 0.01% (Lumigan?0.01%) in the clinical setting
  • Indian Family Angle Closure Evaluation (IFACE) study? Part II
  • A phase 2b double-masked, randomized, active-controlled, dose-response study assessing the safety and ocular hypotensive efficacy of AR-12286 in patients with elevated intraocular pressure for 3 months
  • A phase 2b, double-masked, randomized, active-controlled, study assessing the safety and ocular hypotensive efficacy of AR-12286 in patients with low tension glaucoma
  • A prospective evaluation of open-angle glaucoma subjects randomized to treatment with two trabecular micro-bypass stents in conjunction with cataract surgery or cataract surgery only
  • Luminous: Study to observe the effectiveness and safety of Lucentis through individualized patient treatment and associated outcomes
  • Survey: Glaucoma Awareness in Patients
  • Evaluation of postgraduate clinical education in a tertiary eye care system
  • Cost effectiveness analysis of anti glaucoma medications
  • Genetic analysis of MFRP (Membrane Frizzled Related Protein) and evaluation of phacoemulsification with or without anterior sclerostomy in nanophthalmic eyes
  • A prospective, randomized, controlled clinical trial comparing topical medical therapy with Selective Laser Trabeculoplasty (SLT) as initial treatment for open angle glaucoma in south Indian population
  • Merck - Compare the efficacy and safety of preservative free MK - 2452 (0.0015%) and preservative free Timolate Maleate (0.5%) in patients with POAG and OHT
  • Research study: Genetic screening in a large family with primary open angle glaucoma
Cataract
  • Comparison of refraction stabilization and surgical induced astigmatism between microincision phacoemulsification surgeries
  • Aravind Pseudoexfoliation IOL study- genetic Analysis
  • Comparison of the reduction in IOP, changes in corneal endothelial cell count and anterior chamber angle parameters using ASOCT following clear corneal phacoemulsification with manual small incision cataract surgery
  • To study the safety and efficacy of topical Nepafenac eye drops with topical Prednisolone acetate in patients undergoing YAG peripheral iridotomy
  • Barriers to acceptance of cataract surgery
  • The role of homocysteine in Aravind Pseudoexfoliation IOL Study
  • Clinical evaluation of Toric intraocular lens made by Aurolab
  • The natural history of intraocular lens in eyes with exfoliation syndrome (APEX IOL Study); multicentric
  • Counseling for Cataract Surgery: Effect on patient knowledge, decisional conflict and satisfaction
  • Prospective Review of Early Cataract Outcomes and Grading (PRECOG)
  • A prospective open label observational study to evaluate the safety and surgical performance of surgical blade (Aurosleek) in cataract patients.
  • Comparison of complication rates between Phaco and MSICS at Aravind Eye Hospital
Retina
  • Non randomized control study of comparing 20% Sulphurhexafluride [SF6] with 100% Sulphurhexafluride [SF6] in macular hole surgery
  • Non randomized control study of comparing Sclera Fixated Intraocular Lens [SFIOL] implantation vs Iris Fixated Intraocular Lens [IFIOL] implantation in cases with inadequate posterior capsular support
  • A pilot study comparing the portable retina camera (CavCam XII) to the Topcon Retina Camera
  • AMD phenotype study
  • Visual outcome and optical coherence tomographic features in patients undergoing vitrectomy for Rhegmatogenous retinal detachment
  • Autofluorescence imaging, spectral-domain optical coherence tomography, HFA and visual function correlation in patients with retinitis pigmentosa
  • Study to observe the effectiveness and safety through individualized patient treatment and associated outcomes
  • A 12 month, open label, multicenter study to evaluate the efficacy and safety of intravitreal injections of ranibizumab 0.5mg on cystoids, Spongy and Mixed patterns secondary to Diabetic Macular Edema
  • Genetic analysis of NR2E3 gene in a family with enhanced S cone syndrome and vasoproliferativetumour of retina
  • Study to evaluate utility of DNA macrochip in clinical management and outcomes in endophthalmitis
  • A randomized control study of ILM Peeling with Indocyanine Green, Tryphan Blue and Brilliant Blue dyes used in macular hole surgery
Uvea
  • A phase III, multinational, multicentre, randomized, double-masked, study assessing the safety and efficacy of intravitreal injections of DE-109 (three doses) for the treatment of active, non-infectious uveitis of the posterior segment of the eye.
  • Etiology and immunopathogenesis of subconjunctival and anterior chamber granulomatous uveitis in children
Pediatric
  • Sensitivity and specificity of teachers screening during school screening programme
  • Academic performance of school children-before and after wearing spectacles
  • Training all the class teachers Vs conventional training method- a comparative study
  • Barrier for referrals under 0 - 5 years age group
  • Compliance on wearing spectacles
  • Surgical outcome of large V pattern
Orbit
  • National retinoblastoma registry - ICMR
  • Translational Research to Generate Corneal/Buccal Epithelial Stem Cells with GMP Compliance for Corneal Surface and Socket Reconstruction
  • Identification of mitochondrial biomarkers in retinoblastoma
  • Clinical evaluation of silicone implant for primary or secondary volume rehabilitation of anophthalmic sockets
  • An open label, prospective clinical evaluation of safety and efficacy study of Aurostent (Silicone mono canalicular lacrimal stent manufactured by Aurolab, Madurai, India) in the treatment of canalicular injuries and anomalies
  • Establishing the genetic testing centre for childhood ocular cancer (retinoblastoma) in Aravind Medical Research Foundation
Low vision
  • Effectiveness of low vision referrals: An assessment of patient quality of life and physician perceptions of low vision services at Aravind Eye Hospital
Neuro-ophthalmology
  • Factors affecting the course and outcome of ischemic oculomotor, trochlear and abducens nerve palsy

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