CLINICAL RESEARCH

• Health literacy and barriers to follow-up after initial diagnosis of glaucoma in a South Indian population
• Pharmacoeconomics of various brands of Timolol for patients with glaucoma or ocular hypertension.
• A multi-center, double-masked study of the safety and efficacy of Travoprost APS compared to TRAVATAN® in patients with open-angle glaucoma or ocular hypertension.
• A multicenter, open label, active control, parallel group randomised study to demonstrate non inferiority of Brinzolamide 1% ophthalmic suspension compared with Dorzox (Dorzolamide) 2% ophthalmic solution in treatment of elevated intra-ocular pressure in patients with primary open angle glaucoma or ocular hypertension
• Brinzolamide 1% ophthalmic solution for the treatment of primary open angle glaucoma and ocular hypertension.
• A Prospective non-randomised efficacy and safety clinical trial, 1 year study with a 1 year extension to evaluate the efficacy and safety of ADDI (Aurolab Artificial Drainage Implant) in controlling IOP in refractory glaucomas thereby preventing furthur damage to optic nerve and visual field loss.
• A phase III, randomised, active comparator-controlled, four-week, double –masked clinical trial to compare the efficacy and safety of preservative – free MK-2452 (0.0015%) and preservative- free Timolol Maleate (0.5%) in patients with open angle glaucoma or ocular hypertension in India.
• A multicenter, open-label study to evaluate the safety and efficacy of twice-daily 0.01% Bimatoprost / 0.15% Brimonidine / 0.5% Timolol ophthalmic solution (triple combination) in patients in India, who have glaucoma or ocular hypertension with elevated IOP, and are on twice-daily 0.2% Brimonidine / 0.5% Timolol ophthalmic solution (dual combination) therapy.
• Study protocol for glaucoma counseling and follow-up study.
• Assessing the safety and efficacy of changing to Travacom® (Travoprost/Timolol fixed combination), as replacement therapy in patients with uncontrolled intraocular pressure across India.
• Indian Family Angle Closure Evaluation study (IFACE).
• Assessing safety and efficacy of laser assisted deep sclerectomy in eyes with open angle glaucoma by a non -randomised prospective study.

• Steroids for Corneal Ulcers Trial (SCUT).
• A multi – center, Placebo-controlled, randomised, parallel-group dose-ranging study to assess the efficacy and safety of LX201 for prevention of corneal allograft rejecion episodes or graft failure following penetrating keratoplasty with LX201 implantation in subjects who are at increased immunological risk.
• Mycotic Ulcer Treatment Trial (MUTT).
• Sjögren’s International Collaborative Clinical Alliance (SICCA).

• Role of wetlab training in donor eyes and simulator for learning capsulorhexis.
• Aravind cataract surgical complication study.
• Clinical evaluation of hydrophobic foldable intraocular lenses.
• Comparison of phacoemulsification Vs SICS: A randomised control trial.
• Outcomes of high volume phacoemulsification compared to standard volume phacoemulsification
• The natural history of artificial intraocular lenses in eyes with Exfoliation Syndrome.
• Posterior capsular opacification after implantation of square edge PMMA, round edge PMMA and hydrophobic acrylic intraocular lenses: A prospective, randomised comparative trial.

• A2Z child blindness and eye health project.
• Effect of square edge PMMA IOL in preventing lens epithelial cell migration in paediatric cataract surgery: A randomised controlled trial.
• Lavelle paediatic project Eye Care for Million Children.

• Protocol No.2301; A 24 week multicenter, randomised, double-masked, placebo controlled, dose-ranging phase III study of AIN 457 versus placebo for maintaining uveitis suppression when reducing systemic immunosuppression in patients with quiescent, non-infectious intermediate, posterior or panuveitis (ENDURE study).
• CAIN457C2303: A 24 week multicenter, randomised, double-masked, placebo controlled study to assess the difference in the rate of recurrent exacerbations in Behçet’s patients with posterior or panuveitis treated with AIN457 vs placebo adjunctive to standard-of-care immunosuppressive therapy.
• A double – masked, placebo-controlled, multicentric, parallel group, dose ranging study to assess the efficacy and safety of LX211 as therapy in subjects with non-infectious intermediate, anterior and intermediate, posterior or pan-uveitis.
• First-line Antimetabolites as Steroid-sparing Treatment (FAST) uveitis pilot trial.

• Oral Clonidine premedication in patients undergoing dacryocystorhinostomy under local anaeshtesia
• Prospective clinical evaluation of dacryocystorhinostomy with lacrimal intubation.
• Clinical evaluation of silicone implant for primary or secondary volume rehabilitation of anophthalmic sockets.

• Comparison of the safety and efficacy of Fluocinolone Acetonide intravitreal inserts to sham injection in subjects with diabetic macular edema.
• A 12 month randomised pilot study to compare the efficacy and safety of PDT (standard fluence) plus intravitreal Lucentis vs. PDT (reduced fluence plus intravitreal Lucentis).
• A randomised, parallel group, multicentre, dose finding, comparison of the safety and efficacy of ASI-001A 0.5µG/day and ASI-001B 0.2µG/day Fluocinolone Acetonide Intravitreal inserts to sham injections in subjects with diabetic macular edema.
• Fluocinolone Acetonide for the treatment of diabetic macular edema.
• A safety and efficacy assessment of Vitreosolve® for ophthalmic intravitreal injection for inducing posterior vitreous detachment in non-proliferative diabetic retinopathy subjects.
• Investigation of efficacy and safety in wet AMD-view2 study.
• A multicenter, open study assessing the efficacy and safety of Ranibizumab (intravitreal injections) as adjunctive therapy to laser in patients with visual impairment due to diabetic macular edema (DME).
• MONET STUDY: Protocol BO451001, titled: Phase II multicenter, prospective, randomised, age-related macular degeneration, comparator controlled, and dose ranging study evaluating PF-04523655 versus Ranibizumab in the treatment of subjects with choroidal neovascularisation (MONET study).
• Cardiovascular disease risk in retino-vascular disorders
• A genetic component to the Indeye study of cataract and age – related macular degeneration in India.
• A randomised, double masked, active controlled, phase 3 study of the efficacy, safety, and tolerability of repeated doses of intravitreal VEGF Trap-Eye in subjects either neovascular Age-related Macular Degeneration (AMD).
• A study of featureless retina in diabetic retinopathy: Clinical and angiographic features and therapeutic implications.
• A comparative analysis of pars plana vitrectomy in Rhegmatogenous retinal detachment with macular hole with or without internal limiting membrane peeling.
• A study of polypoidal choroidal vasculopathy: Incidence, angiographic and tomographic features.
• Atypical manifestations of posterior scleritis: Diagnosis and management.
• A restrospective study of anatomic and functional outcome of chronic macula-off rhegmatogenous retinal detachment
• A prospective study of Transpupilary Thermotherapy (TTT) for Chronic central Serous Chorioretinopathy (CSCR)
• Pigment Epithelial Detachment (PED) in Chronic Central Serous Retinopathy.
• Radial optic neurotomy for ischaemic central retinal vein occlusion: A case-control study.
• Laser photocoagulation for diabetic macular edema with serous retinal detachment.
• Optical Coherence Tomography for subhyaloid haemorrhage of various etiologies.
• A study of combined occlusion of central retinal artery and vein.
• Vitrectomy for macula-threatening tractional retinal detachment in diabetic retinopathy.
• Silicone oil tamponade in 23 gauge sutureless vitrectomy: long term anatomical and functional outcome.
• Yag hyaloidotomy with gas tamponade as a viable option for premacular haemorrhage in PDR against surgical intervention by pars plana vitrectomy.
• IVTA Vs macular PHC for diffuse diabetic macular edema–prospective study.
• Isolated intravitreal bevacizumab therapy for choroidal neovascular membranes of multiple aetiologies.
• Intravitreal bevacizumab as a preoperative adjuvant for diabetic macular tractional detachments with active new vessels.
• Intravitreal bevacizumab therapy for polypoidal choroidal vasculopathy.
• Retinochoroidal coloboma - a comparison of laser barrage photocoagulation versus natural history.
• Acute posterior multifocal placoid pigment epitheliopathy with serous retinal detachment: Clinical features and management.
• Evolution and management of macular tractional detachment with a macular hole in the presence of non-perfused hemiretinal vein occlusion.
• Management of rhegmatogenous retinal detachment with macular hole.
• Surgical management of optic nerve pits with macular schisis.
• Occult optic nerve pits with macular schisis.
• Use of “heavy BBG” dye for macular hole surgery.
• Surgery for macular hole secondary to macular telangiectasia.
• Adjuvant role of intravitreal corticosteroid in the surgical management of macular epimacular membrane or hole secondary to uveitis.
• The macular hole coefficient – A novel OCT based mathematical predictor for macular hole closure type.
• A randomised controlled clinical trial comparing panretinal photocoagulation with yellow laser (577nm) versus green laser (532nm) for proliferative diabetic retinopathy.

• Posterior capsular opacification after implantation of square edge PMMA and acrysof intraocular lenses in paediatric cataract: Randomised controlled trial.
• Posterior capsular opacification after implantation of square edge PMMA, round edge PMMA and acrys of intraocular lenses: Randomised controlled study.
• Clinical evaluation of silicone implant for primary or secondary volume rehabilitation of anophthalmic sockets.
• Randomised, active comparator-controlled, three months, open label clinical trial to compare the efficacy and safety of refrigeration-free latanoprost (0.005%) stored at refrigeration temperature in patients with open angle glaucoma or ocular hypertension.
• Clinical evaluation of a new cartridge for the implantation of foldable intraocular lenses.
• Evaluation of safety and efficacy of glaucoma shunt (Aurolab artificial drainage implant) in refractory glaucoma.
• Clinical evaluation of toric intraocular lens made by Aurolab.
• Clinical evaluation of corneal collagen cross linking with riboflavin and ultraviolet for keratoconus.
• Clinical assessment of AuroKPro.